One of the central challenges of rAAV production is the need for a ‘helper virus’ to facilitate replication within a host mammalian cell. In the early days of rAAV, cultured cells would first ...

Newer iterations of the helper-virus-assisted approach improve performance. One strategy converts mammalian cells into ‘packaging cells’ by genetically modifying them to express the AAV genes ...

In this study, we found that human papillomaviruses (HPV) residing in the skin help virus-specific immune cells detect and suppress the expansion of mutant skin cells, thereby promoting the normal ...