One of the central challenges of rAAV production is the need for a ‘helper virus’ to facilitate replication within a host mammalian cell. In the early days of rAAV, cultured cells would first ...
Newer iterations of the helper-virus-assisted approach improve performance. One strategy converts mammalian cells into ‘packaging cells’ by genetically modifying them to express the AAV genes ...
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Q&A: Interplay between immune cells and HPV keeps skin healthyIn this study, we found that human papillomaviruses (HPV) residing in the skin help virus-specific immune cells detect and suppress the expansion of mutant skin cells, thereby promoting the normal ...
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