Naloxone, commonly known by the brand name Narcan, is an opioid-receptor blocker that can reverse opioid overdoses. This easy ...

Naloxone (also known as Narcan, the commonly used drug to treat narcotic overdoses) has greater binding to opioid receptors ...

However, the action of naloxone only lasts about 2 hours before it detaches from the receptor, allowing longer-lasting opioid molecules, such as fentanyl, which can remain in the bloodstream for 8 ...

However, it is only able to occupy pain receptors for 30 to 90 minutes. For more potent opioids, such as fentanyl, that may not be long enough. To determine how the naloxone companion drug, which ...

NOTES: (1) Naloxone is less effective in saving people who have overdosed on fentanyl because fentanyl binds more tightly than heroin to opioid receptors in the brain, so it is more difficult for ...

Further experiments in cells revealed that, in the presence of compound 368, naloxone was 7.6 times more effective at inhibiting the activation of the opioid receptor, partly because naloxone ...

Brandy Schillace’s review of “Candace Pert” by Pamela Rykman (Bookshelf, Nov. 15) contains a questionable conclusion: the discovery of the mu opioid receptor in 1972 “helped launch the ...

Naloxone (orange) treats opioid overdose by kicking out opioids (pink) from the opioid receptor (teal). The newly discovered compound 368 (purple) strengthens the binding of naloxone to the opioid ...

One side effect of naloxone is intense symptoms of opioid withdrawal, but although compound 368 enhances most of naloxone’s actions, it does not seem to enhance withdrawal symptoms.

Background The opioid receptor antagonist naloxone hydrochloride or naloxone has been a significant development in limiting opioid overdose-related deaths and reversing the effects of the overdose.

A standard approach to an opioid overdose includes protection of the airways and administration of a standard naloxone dose, preferably a 0.4- to 0.8-mg intramuscular or intravenous (IM/IV ...

Naloxone is a safe, easy-to-use, life-saving medication that blocks the effects of opioids. Naloxone is an opioid receptor antagonist that can be given through injection or nasal spray.