A new study led by Profs. Fan Kelong and Yan Xiyun from the Institute of Biophysics of the Chinese Academy of Sciences ...

The liver is an attractive target for siRNA delivery because of its important role in numerous diseases and because of the ease at which hepatocytes take up nanoparticles after simple injection.

Similarly, effective knockdown of the NF-κB subunit p50 in cultures of primary human DCs requires treatment with 500 nM siRNA 19, compared with the 10–50 nM required for most established cell ...

In contrast, when RNAi is guided by siRNA, the entire sequence pairs with the target strand ... a technique known as gene knockdown. 8 By delivering dsRNA that are complementary to a target gene’s ...

Company is applying its T cell-selective lipid nanoparticle to develop siRNA therapeutics for T cell-driven autoimmune diseases- Lead target ...

The investigators observed approximately 70% knockdown of GYS1 mRNA and protein ... from the bench to bedside for our Centyrin-siRNA platform.” ABX1100 was well-tolerated at all dose levels ...