In the early days of President Donald Trump's second term, Alaska Sen. Lisa Murkowski has openly challenged or rebuked him at least three times — stunning for a congressional Republican who has faced his wrath before and yet remains unbowed by pressure to embrace his agenda.

A defining duo of the first Donald Trump administration is back.

Lisa Murkowski, the senior United States senator from Alaska, has held the seat since 2002. When will she be up for re-election? Here's what we know.

Moderate GOP Sen. Lisa Murkowski of Alaska has broken her silence, saying she won't be voting to confirm Pete Hegseth as secretary of defense.

At the White House, President Donald Trump said he was surprised that two senators have publicly said they'll vote against his nominee to lead the Defense Department.

We shouldn’t expect McConnell to be the next John McCain or Mitt Romney, but his vote Friday against Pete Hegseth previewed some fascinating dynamics ahead.

The President's order to rename Denali, North America's highest peak, back to Mount McKinley does not agree with Alaska senator.

U.S. Sen Lisa Murkowski was alone in stridently opposing Trump’s blanket pardon for Jan. 6 defendants, and his order to rename Denali as Mount McKinley.

The Alaska Republican’s decision Thursday comes ahead of a crucial test vote to advance Hegseth’s nomination toward confirmation.

Hours after Pete Hegseth cleared a major procedural hurdle in the Senate, President Trump suggested his embattled nominee may not ultimately be confirmed.

Sen. Lisa Murkowski, considered a key GOP swing vote, said she will not be supporting President Donald Trump's Pentagon pick Pete Hegseth. "After thorough evaluation, I must conclude that I cannot ...

President Donald Trump said he was “surprised” that Republican Sens. Susan Collins (Maine) and Lisa Murkowski (Alaska) voted to oppose Pete Hegseth’s defense secretary nomination.