Low-density lipoproteins (LDL)—commonly known as bad cholesterol—have long been on scientists' radar as a major contributor ...

About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users ...

Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this ...

Their approach maps the majority of a human cell's roughly 10,000 kinds of proteins according to the organelles and other compartments containing them, providing a crucial reference to understand ...

The protein IGFBP7, which is secreted from the liver and has been studied in relation to heart failure and kidney damage, turns out to affect insulin secretion in type 2 diabetes.

However, the exact mechanisms behind impaired insulin receptor (INSR) signaling in obesity induced by a high-fat diet remain elusive. In this study, we identify an E3 ubiquitin ligase, tripartite ...

Our findings challenge the existing paradigm that a reduction of SERCA2a is a hallmark of human HF. Even in carriers of the R14del PLN variation, SERCA2a protein levels were unaltered. Although ...

Objectives: The price of analogue insulin has increased dramatically, making it unaffordable for many patients and insurance carriers. By contrast, human synthetic insulins are available at a ...