A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence motif, the RBP binds to the ...

UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

"By targeting key processes like RNA splicing and modification ... from my lab and merge them with Leslie's powerful and robust model systems to nail down this novel mechanism," said co ...

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Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

"By targeting key processes like RNA splicing and modification ... from my lab and merge them with Leslie's powerful and robust model systems to nail down this novel mechanism," said co ...

In myotonic dystrophic patients, titration of MBNL protein by RNA containing expanded CUG repeats leads to expression of a fetal splicing form of the cardiac sodium channel, SCN5A, inappropriate ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...