Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.

A new human-relevant model for studying multi-system pharmacodynamics and toxicity for opioids and opioid overdose treatment ...

The exact mechanism of action is unclear ... of opioid analgesics may result in severe withdrawal symptoms, such as: Naloxone is an FDA-approved medicine used to treat an opioid overdose.

Naloxone administered by the paramedics failed to demonstrate ... After a thorough work up the mechanism of infarct was considered embolic stroke of undetermined source (ESUS). The patient was later ...

Crespo, 39, is among a growing number of homeless pregnant women in California whose lives have been overrun by hard drug use, a deadly coping mechanism ... and credits naloxone, an opioid ...

The overwhelming majority of those in New York City who obtained a naloxone kit to counteract opioid overdose had a high need ...

Accordingly, Ottawa Public Health is pushing a campaign to get naloxone — a medication that can reverse overdoses — into the hands of the public. Just like knowing CPR is an invaluable tool in ...

A literature search identified more than a dozen published reports on the use of pure opioid antagonists (naloxone, naltrexone, methylnaltrexone) for the management of OIP in pediatric and adult ...

Am J Health Syst Pharm. 2011;68(15):1419-1425. The short duration of activity of naloxone when the drug is administered as an i.v. bolus may limit its effectiveness for the management of OIP.